Strenuous running exacerbates knee cartilage erosion induced by low amount of mono-iodoacetate in rats
نویسندگان
چکیده
منابع مشابه
Strenuous running exacerbates knee cartilage erosion induced by low amount of mono-iodoacetate in rats
BACKGROUND It is still debated whether strenuous running in the inflammatory phase produces beneficial or harmful effect in rat knees. We examined (1) the dropout rate of rats during a 30-km running protocol, (2) influences of strenuous running and/or low amounts of mono-iodoacetate injection on cartilage, and (3) the effect of strenuous running on synovitis. METHODS Rats were forced to run 3...
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15 صفحه اولMolecular Mechanism of Cartilage Turnover in Monosodium iodoacetate induced Knee Osteoarthritis
Osteoarthritis (OA) is characterized by a progressive degradation of cartilage and loss of joint function. A simple and reproducible animal model that mimics molecular and pathological changes in the articular cartilage of knee joint OA would help in understanding its pathophysiological mechanism and aid in the preclinical assessment of disease modifying drugs. The aim of our study is to evalua...
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PURPOSE: To evaluate the usefulness of a knee osteoarthritis model through functional, radiological and microscopic changes of the synovial membrane. METHODS: Forty eight rats were divided randomly into two groups. The first received 0.9% saline in the joint and corresponded to the control group. The second was submitted to experimental osteoarthritis of the right knee induced by monosodium i...
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ژورنال
عنوان ژورنال: BMC Musculoskeletal Disorders
سال: 2017
ISSN: 1471-2474
DOI: 10.1186/s12891-017-1393-8